Direct Access to Biology — At the Source

KIFFIK is developing a platform designed to enable direct access to interstitial fluid (ISF), where signals first appear.

Access is the Breakthrough

Interstitial fluid surrounds living cells and reflects local biology. Biomarkers originate in tissue and appear in ISF before dilution and systemic clearance in the bloodstream.

KIFFIK's platform is designed to enable access to this historically underutilized biological fluid, supporting research, clinical investigation, and future monitoring applications.

The Technology Behind the Platform

KIFFIK's platform is enabled by proprietary K-EXP™
technology, designed to support direct access to ISF and the generation of biological information across research and development applications.

  • Noninvasive access
  • Meaningful sample volume:
    Volumes sufficient for downstream molecular analysis.
  • Serial and longitudinal access

From Access to Applications

Biology becomes valuable when it can be accessed. KIFFIK's platform connects direct access to ISF with multiple development pathways across human and animal health.

Development Programs
Enabled by the KIFFIK Platform

The KIFFIK platform, enabled by proprietary K-EXP™ technology, is being developed to support multiple application pathways through direct access to biology, enabled by ISF.

Biomarker Discovery & Drug Development

Advancing biomarker discovery and drug development through direct access to biology. Enabling deeper understanding of therapeutic response, PK/PD relationships, and disease biology.

Oncology

Colorectal cancer is the lead development program, with future expansion opportunities across prostate, pancreatic, breast, and other oncology applications.

Neuroscience

Advancing tissue-level biomarker access for neurological disease, with Alzheimer's disease and traumatic brain injury (TBI) serving as leading development programs.

Multiplex Biology Monitoring

Advancing biological monitoring beyond single-analyte sensing through multiplex biomarker measurement, with lead programs in metabolic monitoring and sepsis detection.

Animal Health

Expanding access to biology in veterinary medicine, with lead programs in equine fertility and bovine dairy health monitoring.

Insights Enabled by Access to ISF

New biological signals revealed beyond matched plasma

Drug exposure and therapeutic response characterized through PK/PD studies

Applications spanning oncology, neuroscience, inflammation, and cardiovascular health

Detection of low-abundance biomarkers associated with disease and therapeutic response

Expanding the Potential of Biological Access

Direct access to biology creates opportunities across biomarker discovery, drug development, disease monitoring, and animal health. KIFFIK is advancing multiple development programs enabled by access to interstitial fluid.

Ready to explore what ISF can do for your pipeline?