For the first time, extraction of bio-rich interstitial fluid (IF) with all its components will be available for multiple health applications. This addition to the medical professional’s toolkit opens the door to a range of opportunities. For scientists, physicians, veterinarians, and hospital professionals, there is the chance to perform continuous or periodic monitoring of critical biomarkers that are prevalent in diseases. The information learned from this fluid can help clinicians, researchers, and biopharmaceutical developers overcome the limitations of plasma and serum monitoring.